Volume : 2, Issue : 11, November - 2013

Neurohistopathological Effects of Gentamycin on Auditory Cortex of Adult Albino Rat

Dr S M Dawar Husain, Dr. M. Rehan Asad, Dr. S. M. Yunus

Abstract :

Getamicin, an aminoglycosidic antibiotic, is ototoxic,nephrotoxic and causes neuromuscular blockade as well. A total of twenty albino rats (10 males and 10 females) were used in the present study, and they were equally divided into control and experimental groups. Experimental group rats received gentamicin intramuscularly for 21 days. Control group rats received normal saline. Then rats of both the groups were anaesthetized with nembutol, 35 mg/kg body wt. and perfused with 10% formalin. 10µ thick sections of auditory cortex were stained with H&E and Thionine. Observation under light microscope revealed degenerative changes.