Volume : 3, Issue : 3, March - 2014

Estradiol Dependant Molecular And Biochemical Changes in Human Spermatozoa

Amit Awasthi, Dr. R. N. Raizada, Rajesh Dubey

Abstract :

 Many of the physiological effects of biphenyl A (BPA) have been described in the context of its ability to interact with classic estrogen receptors. BPA can have estrogenic activity, but it should not be considered to act only as an estrogen or even as a selective estrogen receptor modulator. The available data show that BPA’s biochemical and molecular interactions are complex, involving classic estrogen receptors as well as a variety of other receptor systems and molecular targets. The complex of BPA’s interactions and concentration ranges at which the observations have been made make it challenging to conclude whether a given in vivo finding is biologically plausible based on consistency and potency of a response compared with estradiol alone.