Volume : 4, Issue : 1, January - 2015

A CLINICAL COMPARATIVE STUDY OF MYCOPHENOLATE MOFETIL VERSUS PREDNISOLONE FOR HIGH RISK PENETRATING KERATOPLASTY

Dr Naveen K, Dr Safia Ahmed

Abstract :

<p>Purpose : To study the efficacy and safety of Mycophenolate Mofetil (MMF) in preventing graft rejection in high risk< /> Penetrating keratoplasty(PK) . Methods : Data records of last five years of high risk corneal transplants at two tertiary< /> care hospitals were reviewed. Cases were divided into those who received mycophenolate mofetil for one year versus< /> those who were given systemic steroids. The main outcome measures were immune reaction free &amp; clear graft survival . Results : A total of 400< /> patients ,210 in steroid group and 190 in MMF group, underwent PK in the affected eye including combined Cataract extraction in 146 eyes with< /> mean follow up of 2 years 3 months. Significantly less graft rejection was seen in MMF versus steroid group ( 73 versus 19). Conclusions :Systemic< /> immunosuppression with MMF reduces rejection rate with better corneal graft survival as compared to systemic steroids in high risk PK. </p>