Volume : 4, Issue : 1, January - 2015

Evaluation of Antimicrobial Activity and Phytochemical Analysis of Crude Extracts of Terminalia Paniculata Roth

Mahesh Anand Goudar, H A Sayeswara, S G Manjunatha

Abstract :

<p>The present study was carried out with an objective to investigate the antibacterial and antifungal potentials of bark of< /> Terminalia paniculata Roth. The aim was the study was to assess the antimicrobial activity and to determine the zone of< /> inhibition of ethanolic (EtTP) and ethyl acetate (EATP) extracts of stem bark of Terminalia paniculata against medically< /> important bacterial and fungal stains. The antimicrobial activity was assessed in the extracts using agar disc diffusion method. The antibacterial< /> and antifungal activities of extract (100, 200, 400 &micro;g/ml) of Terminalia paniculata were tested against three gram negative Pseudomonas< /> aeruginosa, Shigella flexneri, Salmonella typhimurium human pathogenic bacteria and one fungal strain Candida albicans. Zone of inhibition< /> of extracts were compared with that of standard drug Streptomycin. The results showed that the significant inhibition of bacterial growth against< /> the tested organisms. Phytochemical analysis revealed the presence of alkaloids, carbohydrate, flavanoids, phenolics, steroids and alkaloids. The< /> antimicrobial activity of Terminalia paniculata was due to the presence of various secondary metabolites. Therefore the bark of the plant can be< /> used to isolate bioactive natural product which may serve as leads in the development of new pharmaceutical research activities.</p>