Volume : 4, Issue : 3, March - 2015
Role of Immunohistochemical Studies in the Classification of Lung Adenocarcinoma and Squamous Cell Carcinoma in Cytologic Specimens : A review of literature
Dr. Nirali Shah, Dr. Cherry Shah, Dr. Biren Parikh, Dr. Deepak Joshi
Abstract :
<p><p>&nbsp;Primary tumours of the lung consist of four principal types; squamous cell carcinoma, small cell carcinoma, large cell&nbsp;</p> <div>carcinoma and adenocarcinoma. The results of several clinical trials identified lung tumor histologic features as a&nbsp;</div> <div>potential prognostic factor and predictor of clinical outcome and response to chemotherapy. Hence, the distinction&nbsp;</div> <div>between different subtypes of NSCLC, particularly adenocarcinoma and squamous cell carcinoma (SCC) has gained importance. Cytologic&nbsp;</div> <div>features of these tumors can overlap, and a variety of superimposed degenerative and mechanical changes can distort the cytologic appearances&nbsp;</div> <div>of the tumor cells. As a result, ancillary techniques such as immunohistochemical analysis have been frequently incorporated into the diagnostic&nbsp;</div> <div>workup of many cytologic and small biopsy specimens.CK5/6 and p63 were used as immunohistochemical markers for SCC, and TTF&ndash;1 and&nbsp;</div> <div>surfactant protein A were markers for Adenocarcinoma</div></p>
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Download PDF Journal DOI : 10.15373/2249555XCite This Article:
Dr. Nirali Shah, Dr.Cherry Shah, Dr. Biren Parikh, Dr. Deepak Joshi Role of Immunohistochemical Studies in the Classification of Lung Adenocarcinoma and Squamous Cell Carcinoma in Cytologic Specimens : A Review of Literature Global Journal For Research