Volume : 4, Issue : 4, April - 2015

Antioxidant Effect of vitamin A & E on Heavy metal (Cd) Induced Renal, Testicular as well as Hepatic injury in Male Albino mice

Rajesh Ku. Meher, Namita Nayak, Bhaskar Behera

Abstract :

<p>&nbsp;Heavy metal toxicity is world threatening problem for human as well as other organism. Heavy metal is widely&nbsp;</p> <div>distributed in environment and some of them occur in food, water, air. Exposure of heavy metal induced oxidative&nbsp;</div> <div>stress and renal and testicular as well as hepatic injury were evaluated in male mice. Present study is desired to find out&nbsp;</div> <div>whether vitamin A &amp; E is able to protect the heavy metal (Cd) stress injury to kidney, liver, testicular abnormality. For these purpose 15 numbers of&nbsp;</div> <div>male albino mice were taken and acclimatization on laboratory condition for about 15 days. 15 mice were divided in to 3 different group each&nbsp;</div> <div>group contain 5 mice first group served as control and was given only distilled water, the second group received distilled water supplemented&nbsp;</div> <div>with Cd 10mg per Kg body weight, third group received distilled water supplemented with 10 mg Cd/kg body weight with Vitamin Cd/kg per day&nbsp;</div> <div>for 90 days. Tissue were collected from both control and treated animals and studied. Mice exposure to Cd show histopathological changes in the&nbsp;</div> <div>liver, kidney, testis but not in Cd supplemented with vitamin A &amp; E</div> <div>&nbsp;</div>