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MENUVolume : 4, Issue : 4, April - 2015
Synthesis, characterisation and antimicrobial studies of 2-[(morpholin-4-yl)(pyridin-3-yl)methyl] hydrazinecarboxamide and its transition metal(II) complexes
S. Farook Basha, M. Syed Ali Padusha
Abstract :
<p><p>&lt;p&gt;&amp;nbsp;CoII, NiII, CuII and MnII complexes of Mannich base, as ligand, was prepared by condensation of aqueous semicarbazide,&amp;nbsp;&lt;/p&gt; &lt;div&gt;morpholine and pyridine&amp;ndash;3&amp;ndash;carboxaldehyde. The structure of the newly synthesized Mannich base was investigated by&amp;nbsp;&lt;/div&gt; &lt;div&gt;UV&amp;ndash;Vis, IR, 1&lt;/div&gt; &lt;div&gt;H&amp;ndash;NMR, 13C&amp;ndash;NMR, molar conductance and magnetic susceptibility studies. The antimicrobial activities of the&amp;nbsp;&lt;/div&gt; &lt;div&gt;ligand and metals complexes have been screened in vitro against the organisms E.faecalis, Proteus mirabilis, Bacillus cereus, E.aerogens, ESBL&amp;nbsp;&lt;/div&gt; &lt;div&gt;E.coli, ESBL K.pneumoniae, by disc diffusion and well diffusion techniques. It is observed that the coordination of metal ions has pronounced&amp;nbsp;&lt;/div&gt; &lt;div&gt;effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligand.&lt;/div&gt;</p></p>
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Download PDF Journal DOI : 10.15373/2249555XCite This Article:
S. Farook Basha, M. Syed Ali Padusha Synthesis, characterisation and antimicrobial studies of [(morpholin–4–yl) (pyridin–3–yl) methyl] hydrazinecarboxamide and its transition metal(II) complexes Global Journal For Research An
