Volume : 4, Issue : 8, August - 2015

Acute exposure to bisphenol-A altered muscular antioxidant system in cichlid fish, Etroplus maculatus (Bloch, 1795)

K. V. Thulasi, K. P. Asifa, K. C. Chitra

Abstract :

<p>The toxic effect of bisphenol A on muscular antioxidant system of fish has not been reported till date. Thus the present study was aimed to understand the effect of bisphenol A on the induction of oxidative stress and its action on alkaline phosphatase activity in muscle of cichlid fish, Etroplus maculatus. Animals were grouped and exposed to sub lethal concentration i.e., 648 &micro;g/ L of bisphenol A for 24 h, 72 h and 96 h. Activities of antioxidant enzymes as superoxide dismutase, catalase and glutathione reductase showed a significant reduction only at 96 h whereas no significant changes were observed at 24 h and 72 h. The level of hydrogen peroxide and lipid peroxidation increased significantly at 72 h and 96 h of exposure when compared to control groups. One of biomarker enzymes, alkaline phosphatase decreased in all treatment groups than that of control groups. In conclusion, bisphenol A induced oxidative stress in muscle thereby altered muscular antioxidant system in cichlid fish, Etroplus maculatus.</p>