Volume : 4, Issue : 9, September - 2015

Monstrous epithelial cell formation in seminal vesicle after Cyclophosphamide treatment

Z. N. Kashmiri, M. S. Sastry

Abstract :

<p>&lt;p&gt;Cyclophosphamide (CPA) is a nitrogen mustard alkylating, anticancer and immunosuppressive agent which is used to treat malignancies such as Hodgkin&lsquo;s disease, leukemia, lymphoma, east and prostate cancer. While studying the effect of various doses (5mg, 7mg and 10mg/KgBW) of Cyclophosphamide on the reproductive tract of male rat some interesting cytotoxic features were observed in the seminal vesicle epithelium (SEV). Intraperitoneal injection of Cyclophosphamide resulted in the formation of monstrous (monster) protruding epithelial cells (MEC) of the seminal vesicle in a clustered pattern with acidophilic cytoplasm, hyperchromatic nuclei, lipochrome pigment in the cytoplasm, very large bizarre nuclei simulating carcinoma cells, spindle cells with multiple discrete areas of anaplastic epithelial-like cells. The seminal vesicles, an androgen dependent organ are among the most important male accessory gland, the formation of monstrous epithelial cell directly suggest anti-androgenic nature of CPA in concomitance with a fall in testosterone level.&lt;/p&gt;</p>