Volume : 4, Issue : 12, December - 2015

EFFECT OF ORAL PREGABALIN AS ADJUVANT TO STANDARD PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSES IN LAPAROSCOPIC SURGERIES.

Satish Patil

Abstract :

<p>&nbsp;Hemodynamic pressor response to the airway instrumentation and surgical stimulation is a hazardous complication of General Anaesthesia.. The aim of present study is to evaluate efficacy of oral pregabalin 150 mg as adjuvant to standard premedication for attenuation of haemodynamic responses to surgical stimulation and compare it with placebo for patients undergoing laparascopic surgeries.A total of 50 adult consented patients aged 18&ndash;65 years, ASA grade I and II, of both gender were randomized into two treatment groups of 25 patients each. Group I received ora pregabalin 150 mg and Group II oral placebo 1 h prior to induction. Anaesthetic technique was standardized and all groups were assessed for pre?operative sedation, haemodynamic changes after the premedication, after laryngoscopy and intubation, along with intraoperative haemodynamic stability and post?operative analgesia and side?effects.Pre?operative sedation levels were higher with pregabalin premedication.Statistically significant attenuation of heart rate and mean arterial pressure was seen in Group I while significant increase in heart rate and mean arterial pressure was observed in Group II after airway instrumentation and also intraoperatively and post operatively. Oral pregabalin 150 mg premedication has adequately sedated the patients with effective attenuation of haemodynamic pressor response of airway instrumentation. The premedicated patients were haemodynamically stable perioperatively without prolongation of recovery time and notable side?effects</p>