Volume : 5, Issue : 4, April - 2016

Role of Clindamycin in complicated falciparum malaria

Dr. M. J Khan, Dr. Milind Suryawanshi, Dr. Pranay Gandhi

Abstract :

<p>&lt;p&gt;&amp;lt;p&amp;gt;&amp;amp;nbsp;Background: The emergence and rapid extension of Plasmodium falciparum resistance to various anti-malarial drugs has gradually limited the potential malaria therapeutics available to clinicians. Methodology: We conducted a clinical trial on 43 admitted paediatric patients with complicated malaria dividing them into 3 groups. Group A received artesunate. Group B received artesunate plus quinine. Group C received artesunate plus quinine plus clindamycin. Results: 74% having convulsions and 48.8% having unconsciousness at the time of presentation. On examination all 100% had splenomegaly, 93% had hepatomegaly, 23.2% had signs of meningeal irritation and 46.5% had signs of dehydration. Out of 8 patients in group A, 2 died. Out of 19 patients in group B, 3 died while there was no mortality in group C. Conclusions: Clindamycin in addition to artesunate and quinine reduces the mortality in complicated malaria but larger studies need to be carried out to warrant the same.&amp;lt;/p&amp;gt;&lt;/p&gt;</p>