Volume : 5, Issue : 4, April - 2016

Dose dependent Effect of silica nanoparticles on rat central Nervous system: A behavioral and biochemical study: Research

Neelima Varshney, Bharat Gupta

Abstract :

<p>&lt;p&gt;&amp;lt;p&amp;gt;&amp;amp;nbsp;Occupational exposure to silica dust has been increasing the possible risk of varieties of pathologies. It has also been found extensive applications in biomedical and biotechnological fields such as medical diagnostics, drug delivery, gene therapy, biomolecules detection, photodynamic therapy and bio-imaging. This adds to the increasing industrial exposure to silica nanoparticles during production, transportation, storage, and consumer use by which human exposure and environmental burden were obviously increased. The purpose of this work was to investigate the neurotoxicity of two different dosages (40 and 80 mg /kg body weight) of silica nanoparticles (SiNPs) in Wistar rats for 14 days by intraperitoneal exposure. The neurobehavioral and neurochemical changes were analyzed. Spontaneous motor activity, catalepsy, gait and muscle incoordination were assessed. Thereafter ain was removed for investigation of lipid peroxide level and antioxidant enzymes (SOD and CAT). Our results showed SiNPs could pass through the blood ain barrier into the ain. Significantly increases the concentration of lipid peroxide levels and reduces the activity SOD and CAT and reduced behavioural activity were seen. The maximum changes were observed in rats who received 80 mg dose. We conclude that neuronal toxicity of silica nanoparticles could be related to the amount of the particle. Oxidative stress could be involved in cellular damage by lipid, protein and DNA and cognitive decline.&amp;lt;/p&amp;gt;&lt;/p&gt;</p>