Volume : 5, Issue : 6, June - 2016

Relationship between Body Mass Index and Mucosal Disease in Crohn’s Diseases Patients at Bhuj, Gujarat, India: a Case-Control Study

Dr. Kashyap Buch, Dr. Sachin Thacker

Abstract :

<p>&lt;p&gt;&amp;nbsp;Background: In the past few decades, the prevalence of obesity all through the world has noticeably increased. This trend in obesity is reflected in patients with Crohn&amp;rsquo;s disease (CD) as well. Present study was done with to test the theory that CD patients with higher BMI would be more likely than those with lower BMI to have determinedly active mucosal (endoscopic) disease. Methods: Present study was a retrospective case-control study of patients attending at the Gujarat Adani institute of medical science, Bhuj, Kutch, Gujarat. Sample population consisted of CD patients with active disease at the commencement of observation. At the end of observation, cases had persistent active mucosal disease and controls had entered reduction. With multivariable logistic regression models, we evaluated the effect of baseline BMI as a continuous variable and a categorical variable on persistent active mucosal disease. Results: We analyzed data from 104 patients (36 cases and 68 controls). In a model containing BMI as a continuous variable, higher BMI was significantly connected with persistent active mucosal disease in a model containing BMI as a categorical variable, obese patient were 2.7 times more expected to have importunate active mucosal disease in comparison to non-obese patients. Conclusion: Extreme weight calculated both quantitatively as BMI and categorically as obesity in CD patients is linked with constant active mucosal disease.&lt;/p&gt;</p>