Volume : 5, Issue : 8, August - 2016

A Comparative study of combination of low-dose Ketamine and Midazolam versus Ketamine and Midazolam alone as Oral Premedication in paediatric population

Dr. Lakshmi Prakash, Prof. Dr. C. Anuradha

Abstract :

<p>&nbsp;Background: Oral premedication is an easily acceptable alternate route of achieving a calm, sedated child for smooth induction of anaesthesia. Oral premedication has a good patient compliance and is very easy to administer. A calm child entering the operation theatre also provides parental satisfaction, removing fears from their minds too. Oral Ketamine and oral Midazolam have been tried for the last 20 years as good premedicants with varying results. A combination of low-dose oral Midazolam and Ketamine has been used in this study to find out whether there is advantage in terms of minimal side-effects, sedation onset when compared to individual drugs. An ideal atraumatic premedicant can provide effective analgesia and also minimize separation anxiety, improve induction by mask-acceptance, minimize emotional trauma and have decreased occurrence of negative behavioral issues. The combination of oral low dose Ketamine at 3 mg/kg and Midazolam at 0.25 mg/kg is more efficacious when compared to individual oral Midazolam at 0.5 mg/kg and individual oral Ketamine at 6 mg/kg in terms of better onset of sedation, adequate depth of sedation, anxiolysis, hemodynamic stability and good, smooth post-operative recovery</p>