Volume : 5, Issue : 8, August - 2016

STATUS OF ER,PR,HER2neu IN BREAST CARCINOMA AND ITS RELATION TO HISTOPATHOLOGY IN DETERMINING THE SURVIVAL RATE

Abhishek Verma, Dr Prabhat Kumar Raina, Somya Sinha

Abstract :

<p>&nbsp;Aim : ER, PR and Her 2neu plays an important role in prognosis and determines the therapeutics in carcinoma east. This study determines the hormone receptor status and its relation to histopathology. Methods: This study was conducted at cancer hospital, Ranchi where one twenty eight case were assessed for the ER, PR, and Her 2neu status by immunohistochemistry along with histopathology in trucut biopsy as well as modified radical mastectomy specimen. Results: 128 samples were studied for expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (Her 2neu). About 22.6 % cases had ER positive status while 19.5 % and 12.5 % were PR and Her2neu positive respectively. ER was negative in 10.1 % cases with PR negativity being 12.5 %. Her2 neu was negative in 17.1 % cases and equivocal (score 2) was seen in 5.4 % cases. Maximum number of patients were between the age group of 40-49 years. Lymph nodal involvement was seen in 31.2 % cases. 78.1 % cases had Modified Bloom Richardson grade III histologically of infiltrating duct carcinoma. (IDC) Conclusion: Hormone studies helps to determine the overall disease along survival. Triple negative cases (ER/PR-, Her2-) had worst survival along with compared to the other subtypes. Histological subtypes and hormone status determines the prognostic and predictive value as well.</p>