Volume : 5, Issue : 7, July - 2016

OUTCOME OF BIRTH ASPHYXIA MANAGED WITH MAGNESIUM

Pendurthi Venkata Krishna, Abhishek Mahankali V

Abstract :

<p>&nbsp;INTRODUCTION: Until recently, management strategies of birth asphyxia were supportive and not targeted toward the processes of ongoing injury. In view of conflicting reports about the role of magnesium in birth asphyxia and also due to the paucity of Indian studies in this part of Telangana, the present study was undertaken. OBJECTIVE: To study the outcome and complications of term asphyxiated neonates in first 10 days of life who are supplemented with Magnesium. METHODOLOGY: Randomized case control study on 85 term neonates with birth asphyxia(45 cases and 40 controls). All the term neonates with Apgar score of 3 or less at 1 minute and 6 or less at 5 minutes were included in the study. Cases had received Magnesium Sulfate intravenous infusion at a dose of 250 mg/kg in first hour of life and 2 additional doses of 125 mg/kg at intervals of 24 hours. Serum Magnesium was estimated at birth and then on 12, 24, 48 and 72 hours of life in both groups. RESULTS: Mean number of convulsions was 4.6 in cases and 7.2 in control group. Time interval between the first and last convulsion was less in cases as compared to control group. Duration of Oxygen supplementation and NICU stay were significantly shorter in cases. Direct east feeding was able to initiate early in case as compared to controls group. Significant differences in Magnesium level were seen in cases after supplementation. Clinical or Serum Magnesium toxicity were detected in any of the cases. There was no difference in incidence of complications among the two groups. CONCLUSION: Decrease in the number of convulsion and duration of convulsion shows the neuroprotective effect of Magnesium in treatment of birth asphyxia. In the present study magnesium supplementation regimen was not associated with toxicity</p>