Volume : 5, Issue : 11, November - 2016

EVALUATION OF MICROCYTIC HYPOCHROMIC ANAEMIA BASED ON SERUM.FERRITIN

Dr. Najma R. A, Dr . Divya. J, Dr. V. Eswari, Dr . V. Banumathy

Abstract :

<p>&nbsp;INTRODUCTION: Microcytic hypochromic anaemia is characterised by decreased haemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and normal to increased red cell distribution width (RDW). The peripheral blood smear shows microcytic cells containing less Hb (hypochromic), anisocytosis and poikilocytosis. Serum ferritin(S.Ferritin) concentrations suggests the level of circulating ferritin related to body stores of iron. Ferritin iron forms a reserve which can be drawn on when necessary for the synthesis of haemoglobin or other iron containing compounds. This is of particular importance in states of negative iron balance, and under these conditions storage iron is mobilized and eventually entirely depleted. AIM: A descriptive study to evaluate microcytic hypochromic anemia based on Serum.Ferritin (S.Ferritin). MATERIALS AND METHODS: 1123 patients were referred to our lab with anaemia for investigations. 100 patients were selected for the study after proper clinical examination, history taking and screening for microcytic hypochromic anaemias. Peripheral smear examination, hematological parameters and S.Ferritin were done for the selected100 samples . RESULTS: S.Ferritin levels are decreased in Iron deficiency anemia (IDA ),increased in Anemia of chronic disease(ACD) and decreased to normal in combined anaemia of chronic disease and iron deficiency anaemia. CONCLUSION: S.Ferritin along with peripheral smear examination and automated haemogram are helpful in distinguishing iron deficiency anaemia and anaemia of chronic disease, but not helpful in distinguishing them from combined anaemia of chronic disease and iron deficiency anaemia.</p>