Volume : 5, Issue : 12, December - 2016

Comparison Of The Effects Of Low Dose Vasopressin On Haemodynamic Parameters In Septic Shock Patients At Two Different Time Intervals

Dr Amit Rai, Dr Josemine Davis, Dr Rajneesh Joshi

Abstract :

<p>&nbsp;<b><span style="font-family:&quot;Arial&quot;,sans-serif;color:#1A1A1A">Background</span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><span style="font-family:&quot;Arial&quot;,sans-serif">One of the major concerns in patients with septic shock is <span class="A2">hypotension resistant to conventional catecholamines.&nbsp; We studied the effects of low dose vasopressin on the hemodynamic parameters of these patients at two different time intervals. </span><span style="color:#1A1A1A"><o:p></o:p></span></span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-family:&quot;Arial&quot;,sans-serif;&#10;color:#1A1A1A">&nbsp;</span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><b><span style="font-family:&quot;Arial&quot;,sans-serif;color:#1A1A1A">Methods<o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%;mso-pagination:none;mso-layout-grid-align:none;text-autospace:&#10;none"><span style="font-family:&quot;Arial&quot;,sans-serif">Patients with catecholamine resistant septic shock were included and vasopressin infusion was started at 0.04 units/min for 24 hours. Hemodynamic parameters were recorded at 0,8 and 24 hours.<span style="color:red"> </span><span style="color:#1A1A1A"><o:p></o:p></span></span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-family:&quot;Arial&quot;,sans-serif;&#10;color:#1A1A1A">&nbsp;</span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><b><span style="font-family:&quot;Arial&quot;,sans-serif;color:#1A1A1A">Results<o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%;mso-pagination:none;mso-layout-grid-align:none;text-autospace:&#10;none"><span style="font-family:&quot;Arial&quot;,sans-serif">After eight hours of the initiation of vasopressin infusion, there was a significant increase in blood pressure, and SvO2 and decrease in heart rate. There was a significant increase in hemodynamic parameters (including urine output) at the end of 24 hours. <span style="color:#1A1A1A"><o:p></o:p></span></span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-family:&quot;Arial&quot;,sans-serif;&#10;color:#1A1A1A">&nbsp;</span></p> <p class="MsoNormal" style="line-height:200%;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><b><span style="font-family:&quot;Arial&quot;,sans-serif;color:#1A1A1A">Conclusion<o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%;mso-pagination:none;mso-layout-grid-align:none;text-autospace:&#10;none"><span style="font-family:&quot;Arial&quot;,sans-serif">Beneficial effects of low dose vasopressin are more pronounced if continued for 24 hours.<o:p></o:p></span></p>