Volume : 5, Issue : 12, December - 2016
Characterization of leiomyomatoid angiomatous neuroendocrine tumour (LANT)-like tumour of the myometrium with histopathological examination.
Takuma Hayashi
Abstract :
<p> <span style="font-size: 12pt; font-family: "Times New Roman", serif;">Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is a possible new disease entity that was described as a dimorphic neurosecretory tumour with a leiomyomatous vascular component; it was found in the pituitary. We describe here uterine LANT-like tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">-</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">positive endothelium and smooth muscle actin</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">-</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules. Both vascular and stromal components diffusely expressed chromogranin A. </span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">Histopathological examinations of uterine LANT-like tumour revealed the common characteristic abnormalities of uterine mesenchymal malignant tumours, i.e. leiomyosarcomas</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">. Our research findings show that defective expression of CALPONIN h1 and proteasome <i>beta</i> 9 (PSMB9)/</span><span style="font-size: 12pt; font-family: Symbol;">b</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;">1i is observed in uterine LANT-like tumour such like immune-pathological findings of uterine leiomyosarcoma. These findings meet the definition of uterine LANT-like tumour, and the occurrence of our case suggests that LANT is a special type of neuroendocrine neoplasm and is</span><span style="font-size: 12pt; font-family: "Times New Roman", serif;"> not organ specific.</span></p> <p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;mso-font-kerning: 0pt"><o:p></o:p></span></p>
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Download PDF Journal DOI : 10.15373/2249555XCite This Article:
Takuma Hayashi, Characterization of leiomyomatoid angiomatous neuroendocrine tumour (LANT)-like tumour of the myometrium with histopathological examination., Global Journal For Research Analysis,Volume : 5 | Issue : 12 | December 2016