Volume : 6, Issue : 1, January - 2017

A STUDY ON HEMATOLOGICAL MANIFESTATIONS OF ALCOHOL

Dr. Venkateshwarlu Rajuri, Dr. K. Kishore Kumar

Abstract :

BACK GROUND:              Alcohol consumption is one of the commonly practiced social evils in the new era and is known for morbidity and mortality. Alcohol induced diseases are common and are well documented by many of the earlier studies but only at a later stage. Limited data is available to detect the early alterations caused by Alcohol abuse. Multiple organs can be involved like Hepatobiliary system, Cardio vascular system, Central nervous system, Haemopoietic system. <o:p></o:p>                 Alcohol can lead to all types of anemia with suppression of bone marrow. Many a times hematological changes are left undetected and untreated. Alcoholism is considered a progressive disease, meaning that the symptoms and effects of drinking alcohol become increasingly more severe over time.<o:p></o:p> AIM: To describe hematological changes in respect to the quantity and duration of alcohol consumption.<o:p></o:p> OBJECTIVES: To study the hematological indices (Hb%, MCV, PLATELET COUNT) in alcoholics <o:p></o:p> MATERIALS AND METHODS:<o:p></o:p> 50 chronic alcoholics admitted in Chalmeda Anand Rao Institute of Medical Sciences between January, 2014 and December, 2015 included in the study. Depending upon the quantity and duration of alcohol consumption they were categorized to moderate alcoholics and severe alcoholics, each group consists of 25 alcoholics and Hematological parameters were studied in both groups.<o:p></o:p> RESULTS:<o:p></o:p> The mean haemoglobin was 9.208gms% in moderate alcoholics and 9.564 gm% in severe alcoholics. The mean of white blood cells 8116.00±3433.497 in moderate alcoholics and 11380.00±7265.845 in severe alcoholics. The mean MCV in moderate alcoholics was 90.828±11.4819fl and severe alcoholics 93.624±9.4036 fl.. <o:p></o:p>           Normocytic normochromic anemia was present in 16% (8/50) of patients, microcytic hypochromic anemia in 22% (11/50) macrocytic anemia in 36% (18/50) patients.<o:p></o:p>          Abnormal bone marrow picture was seen in 38% (19/50) patients. Among which megaloblastic picture was seen in 24% (12/50) of alcoholics, Erythroid hyperplasia was seen in 22% (11/50). Vacuolated RBC was seen in 10% (5/50).Sideroblasts was seen in 8% (4/50) of alcoholics.<o:p></o:p> CONCLUSIONS:<o:p></o:p>                  Anemia was the predominant feature among chronic alcoholics. All types of anemia were seen in alcoholics.Bone marrow studies reveal predominantly megaloblastic  picture. Increased vacuolization in pro normoblasts precursors of red blood cells, megaloblastic picture and erythroid hyperplasia, Sideroblastic and myelodysplastic picture was also seen. Severity of anemia was not related to the severity of alcohol intake but with an increased risk of infection among alcoholics.<o:p></o:p>

Keywords :

NORMOCYTIC NORMOCHROMIC MEGALOBLASTIC

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

Dr. VENKATESHWARLU RAJURI, Dr. K. KISHORE KUMAR, A STUDY ON HEMATOLOGICAL MANIFESTATIONS OF ALCOHOL, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-1, January‾2017