Volume : 6, Issue : 1, January - 2017

A tertiary care center study from Southern India on evaluating relationship of microalbuminuria with glycosylated hemoglobin and disease duration in type 2 diabetes mellitus

Vaishali A Jain, Rajesh S Patil, Anuradha G Patil, Sainath K Andola

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span lang="FR" style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:FR">Objective: </span></b><span style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif;">Diabetes Mellitus&nbsp; is a major cause of morbidity and mortality as a result of its complications. Long-term complications have been linked to poor glycaemic control. Microalbuminuria has been identified as predictors of diabetic nephropathy which is the leading cause of end stage renal disease. This study was conducted to correlate and statistically analyse the relation between microalbuminuria with glycosylated hemoglobin (HbA1c) and disease duration.</span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;&#10;text-align:justify;line-height:200%"><b><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">Material and Method: </span></b><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,serif;&#10;mso-ansi-language:EN-IN">The present prospective study was conducted in Basaveshwar Teaching and General Hospital, Kalaburagi for 06 months.</span><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">Laboratory tests as HbA1c, urine microalbumin and urine creatinine were measured in semiautomated biochemistry analyser. Ratio of microalbumin to creatinine was considered as a measure of microalbuminuria. <o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;&#10;text-align:justify;line-height:200%"><b><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">Results: </span></b><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">Out of 330 cases, 117 cases (35.45%) were of microalbuminuria. The mean age was 51.7&plusmn;10.5 years. There was male preponderance (65.8%) and duration of diabetes was 6.6&plusmn;</span><span lang="SV" style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:SV">3.4 years. </span><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">HbA1c level was 7.3&plusmn;</span><span lang="SV" style="font-family:&quot;Times New Roman&quot;,serif;&#10;mso-ansi-language:SV">1.4%.&nbsp; </span><span style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-US">There was significant positive correlation between microalbuminuria and HbA1c and between microalbuminuria and duration of diabetes. <o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;&#10;text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,serif;mso-ansi-language:EN-IN">Conclusion: </span></b><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,serif;&#10;mso-ansi-language:EN-IN">The present study suggests using microalbuminuria as a method to understand glycemic control in individuals with type 2 Diabetes and emphasizes the importance of regular evaluation of microalbuminuria in all type 2 diabetic patients for timely therapeutic intervention and prevention of renal complications.</span><span style="font-family:&quot;Times New Roman&quot;,serif;&#10;mso-ansi-language:EN-US"><o:p></o:p></span></p>