Volume : 6, Issue : 1, January - 2017

Risk of Acute Kidney Injury and Chronic Kidney Disease in Pre-eclampsia

Hanadi M. Alhozali, Samera F. Albasri, Aisha A. Alzabedi, Hisham A. Makki, Hanin A. Alsini

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Background:</span></b><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"> Pre-eclampsia is new-onset hypertension with proteinuria in pregnancy. Some patients may develop acute kidney injury (AKI) due to pre-eclampsia. However, very few studies link the risk of developing chronic kidney disease (CKD) due hypertension in pregnancy. This study aims to determine the prevalence of AKI and the association between pre-eclampsia and future risk for CKD.</span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Methods: </span></b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">This single-center retrospective study was conducted in the western region of Saudi Arabia on patients diagnosed with pre-eclampsia between 2010 and 2015. The records of each patient were taken into consideration and the data were statistically analyzed. The binary logistic regression model was used for the independent variable &lsquo;pre-eclampsia with AKI&rsquo; and the dependent variable &lsquo;CKD&rsquo;.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Results: </span></b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">A</span><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"> total of 568 patients were included. Pre-eclampsia together with AKI strongly influenced the risk for CKD. The prevalence of AKI was similar to those reported in studies conducted in developed countries.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Conclusion: </span></b><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Patients with AKI and pre-eclampsia have a greater risk of developing CKD. However, the association between CKD and AKI needs to be studied further. Additionally, patients with pre-eclampsia should have regular follow-up, be given adequate information on the disease, and be treated and informed of the risk of cardiovascular disease.&nbsp;<o:p></o:p></span></p>