Volume : 6, Issue : 1, January - 2017

Antioxidant and anti diabetic activities of leaf and flower extracts from Acacia auriculiformis A. Cunn. ex Benth.

Buavaroon Srichaikul, Gordon Bakker

Abstract :

Introduction and Objective: Acacia auriculiformis A. Cunn. ex Benth. belongs to the Fabaceae family of flowering plants and has been reported to have useful medicinal properties such as those that control stomach diseases, aid contraception and facilitate abortion. It has recently been used as an alternative and complementary treatment for diabetes. Although there is considerable anecdotal information about the antidiabetic activity of this plant, much of this has not been substantiated by scientific evidence. The present study therefore, was aimed to investigate the antioxidant and antidiabetic activities of leaf and flower extracts from Acacia auriculiformis A. Cunn. ex Benth.   Methods: Leaves and flowers  of Acacia auriculiformis A. Cunn. ex Benth.  were extracted by macerating in 80% ethanol. Antioxidant activity of leaf and lower  extracts(AALE and AAFE ) from Acacia auriculiformis A. Cunn. ex Benth. was performed using DPPH scavenging analysis. The antidiabetic activity was carried out by a once daily oral application of the extracts at a dose of 250 mg/kg to normal and streptozotocin (65 mg/kg)-induced diabetic rats for 8 weeks to determine fasting blood glucose level, body weight, serum insulin, and blood chemistry in the rats.<o:p></o:p>     Results: The results revealed that AALE and AAFE possessed relatively low antioxidant activity compared to a standard     ascorbic acid with IC50 at 296.10+16.40 and 839.56+21.53 and 1.48+0.07 µg/ml respectively. The extracts significantly (p<0.05) reduced fasting blood glucose, blood urea nitrogen (BUN), creatinine, albumin, alkaline phosphatase (ALP), and total protein, while significantly increasing serum insulin in the diabetic treated rats compared to the diabetic controls.      <o:p></o:p>                 Conclusion: These findings indicate that the leaves and flower extracts from Acacia auriculiformis A. Cunn. ex Benth.<o:p></o:p>  possess antioxidant and antidiabetic activities that lower the fasting blood glucose level by increasing insulin secretion. <o:p></o:p>

Keywords :

Acacia auriculiformis A. Cunn. ex Benth. diabetic rats antidiabetic activity antioxidant serum insulin

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

Buavaroon Srichaikul, Gordon Bakker, Antioxidant and anti diabetic activities of leaf and flower extracts from Acacia auriculiformis A. Cunn. ex Benth. , GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-1, January‾2017