Volume : 6, Issue : 2, February - 2017

Role of antiphospholipid antibody in early pregnancy loss

Dr. Shushila Kharkwal, Dr. Sanjaya Sharma, Dr. Rajkumar Mishra, Dr. Heena Khan

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 10pt;">Antiphospholipid anitibodies are a group of autoantibodies that bind to negatively charged phospholipids. These antibodies have been associated with thrombotic events which lead to pregnancy loss. A study was conducted in the Department of obstetrics &amp; gynecology,MLB medical college, Jhansi, to detect and establish a correlation between antiphospholipid antibodies in early pregnancy losses. MATERIAL &amp; METHOD- the study included 70 patients between 16-35 years of age.45 patients were having history of 2 or more spontaneous abortion and 25 patients were having normal obstetrical history. Anticardiolipin antibodies were measured by ELISA method. Both IgG and IgM types of aCL</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 10pt;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 10pt;">were measured. RESULTS-</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 10pt;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 10pt;">3/45 patients were found to be positive for antiphospholipid antibody in group having 3 or more abortions while 0/25 were positive in group having normal obstetric history. CONCLUSION-We concluded that antiphospholipid antibody have association with recurrent abortion(7%) especially during first trimester.&nbsp;</span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>