Volume : 6, Issue : 2, February - 2017
A STUDY TO DETERMINE EFFECT OF HAART (HIGHLY ACTIVE ANTIRETROVIRAL THERAPY) ON CSF VIRAL LOAD IN PATIENT WITH HIV INFECTION
A. D. Mathur, Devesh S
Abstract :
<p> <b style="text-align: justify; font-size: 12px;"><i><u><span style="font-size:14.0pt; line-height:150%;font-family:"Times New Roman",serif;color:#C00000">INTRODUCTION</span></u></i></b><b style="text-align: justify; font-size: 12px;"><i><span style="font-size:14.0pt;line-height:150%;font-family:"Times New Roman",serif; color:#C00000">:</span></i></b><i style="text-align: justify; font-size: 12px;"><span style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif"> With the introduction of highly active antiretroviral therapy (HAART) there has been significant reduction in morbidity and mortality due to HIV infection which has now become a chronic disease. Another important aspect is effect of antiretroviral therapy on CSF HIV-1 RNA levels. </span></i><b style="text-align: justify; font-size: 12px;"><i><u><span style="font-size:14.0pt;line-height:150%;font-family:"Times New Roman",serif; color:#C00000">MATERIAL AND METHODS</span></u></i></b><b style="text-align: justify; font-size: 12px;"><i><span style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; color:#C00000">: </span></i></b><i style="text-align: justify; font-size: 12px;"><span style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif">Twenty HIV positive patients with neurological manifestations and twenty patients of HIV without any neurological manifestation were enrolled. Detailed history regarding time and mode of detection of HIV infection and time of starting HAART was recorded. All patients underwent a detailed clinical examination with emphasis on neurological examination. Lumbar puncture was done and CSF examination was carried out in all forty patients (HIV patients with and without neurological manifestation). CSF was subjected to cytological, biochemical and bacteriological analysis and HIV viral load estimation. Simultaneously blood samples were collected from all patients for plasma viral load estimation. </span></i><b style="text-align: justify; font-size: 12px;"><i><u><span style="font-size:14.0pt;line-height: 150%;font-family:"Times New Roman",serif;color:#C00000">RESULTS</span></u></i></b><b style="text-align: justify; font-size: 12px;"><i><span style="font-size:14.0pt;line-height:150%;font-family:"Times New Roman",serif; color:#C00000">:</span></i></b><i style="text-align: justify; font-size: 12px;"><span style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif">In our study all the cases (HIV/AIDS patients with Neuro AIDS) and controls (HIV/AIDS patients without Neuro manifestations) were males only. 45% of the cases and 60% of controls were in the age group of 25 to 35 yrs and 35 % of cases and 40% of controls were in age group of 36 to 45 yrs. Among cases (HIV patients with neurological manifestations), 60% were on HAART (>1 month) while among controls (HIV positive patients without any neurological manifestations, only 5% were on HAART (>1 month).</span></i><b style="text-align: justify; font-size: 12px;"><i><u><span style="font-size:14.0pt;line-height:150%;font-family:"Times New Roman",serif; color:#C00000">CONCLUSION</span></u></i></b><b style="text-align: justify; font-size: 12px;"><i><span style="font-size:14.0pt; line-height:150%;font-family:"Times New Roman",serif;color:#C00000">: </span></i></b><i style="text-align: justify; font-size: 12px;"><span style="font-size:12.0pt;line-height: 150%;font-family:"Times New Roman",serif">CSF viral loads are much lower in HAART treated HIV positive patients with and without neurological manifestations as compared to treatment naive patients.</span></i></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align: justify;text-justify:inter-ideograph;line-height:150%"><b><i><u><span style="font-size:14.0pt;line-height:150%; font-family:"Times New Roman",serif;color:#C00000"><o:p></o:p></span></u></i></b></p>
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Cite This Article:
A.D. Mathur, Devesh S, A STUDY TO DETERMINE EFFECT OF HAART (HIGHLY ACTIVE ANTIRETROVIRAL THERAPY) ON CSF VIRAL LOAD IN PATIENT WITH HIV INFECTIONGLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-2, February‾2017