Volume : 6, Issue : 2, February - 2017

ROLE OF LEPTIN IN HYPOTHYROID COMPLICATIONS

Dr. Satwika Sinha, Dr. Kaushik Kar, Dr. Rituparna Pal, Dr. Anindya Dasgupta

Abstract :

<p>&nbsp;<b style="font-size: 12px;"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">Background: </span></b><span style="font-size: 12pt; line-height: 115%; font-family: &quot;Times New Roman&quot;, serif;">Thyroid hormones are the fine regulators of metabolism. Any alteration of thyroid profile can affect the lipid metabolism. Leptin from adipose tissue can also alter both the thyroid hormone and lipid metabolism. <b>Aim :</b> In present study, we compare serum fasting leptin and LDL levels in&nbsp; hypothyroid patients when compared to healthy subjects and their effect on developing further complications. <b>Statistical Analysis:&nbsp; </b></span><span style="font-size: 12px; font-family: &quot;Times New Roman&quot;, serif;">Done by SPSS software 17 version.</span><b style="font-size: 12px;"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">Material and method : </span></b><span style="font-size: 12pt; line-height: 115%; font-family: &quot;Times New Roman&quot;, serif;">60 hypothyroid patients and 30 age and sex matched controls are selected. Serum TSH ,leptin, LDL was estimated. <b>Results</b> : TSH ,leptin and LDL is significantly different in case than control.Those who are having LDL &gt; 160mg/dl is having significantly high leptin than the control group. <b>Discussion &amp;</b> <b>Conclussion</b> :&nbsp; hypothyroid patients are having dyslipidemia. Leptin&nbsp; is having a role in&nbsp; cholesterol synthesis and lipid clearance.It is also having a regulating effect on TSH also.So leptin itself can aggrevate the dyslipidemia associated cardiovascular risk factors of hypothyroidism.&nbsp;</span></p> <p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>