Volume : 6, Issue : 4, April - 2017
PROGNOSTIC IMPLICATIONS OF MICROALBUMINURIA IN NON-DIABETIC, NON-HYPERTENSIVE PATIENTS WITH ACUTE CORONARY SYNDROME
Suprabhat Giri, Namita Mohanty
Abstract :
<p> <b style="text-align: justify;"><span lang="EN-IN" style="font-size:12.0pt; font-family:"Times New Roman",serif">Background:</span></b><span lang="EN-IN" style="text-align: justify; font-size: 12pt; font-family: "Times New Roman", serif;"> Microalbminuria is a major risk factor predisposing to cardiovascular morbidity and mortality but very limited evidence are there to suggest it’s use as a prognostic tool to determine in-hospital morbidity and mortality. The aim of this study was to examine the presence of microalbuminuria as a predictor of major adverse cardiac events in non-diabetic,non-hypertensive patients with acute coronary syndrome.</span></p> <p class="MsoNormal" style="text-align:justify;line-height:normal;tab-stops:116.25pt"><b><span lang="EN-IN" style="font-size:12.0pt; font-family:"Times New Roman",serif">Methods:</span></b><span lang="EN-IN" style="font-size:12.0pt;font-family:"Times New Roman",serif"> Fifty five non-diabetic, non-hypertensive patients with acute coronary sydrome were studied prospectively. A comparison of in-hospital mortality and major non-fatal in-hospital events between microalbuminuric and normoalbuminuric patients was done.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:normal"><b><span lang="EN-IN" style="font-size:12.0pt; font-family:"Times New Roman",serif">Results:</span></b><span lang="EN-IN" style="font-size:12.0pt;font-family:"Times New Roman",serif"> In the study group 52.7% patients developed an in-hospital event (fatal or non-fatal). Microalbuminuric had a higher mortality rate in comparison with normoalbuminuric but it was not significant (p=0.146). The incidence of arrhythmias (p=0.029) and cardiogenic shock (p=0.042) were significantly higher in patients with microalbuminuria. The combined end-point of the total number of fatal and non-fatal events was significantly higher in patients with microalbuminuria (p=0.002). In multiple logistic regression analysis, microalbuminuria (p=0.030) was independently related to the occurrence of major in-hospital events.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:normal"><b><span lang="EN-IN" style="font-size:12.0pt; font-family:"Times New Roman",serif">Conclusions:</span></b><span lang="EN-IN" style="font-size:12.0pt;font-family:"Times New Roman",serif"> Microalbuminuria is a significant predictor of in-hospital morbidity and mortality in non-diabetic patients with acute myocardial infarction.<o:p></o:p></span></p>
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Cite This Article:
SUPRABHAT GIRI, NAMITA MOHANTY, PROGNOSTIC IMPLICATIONS OF MICROALBUMINURIA IN NON-DIABETIC, NON-HYPERTENSIVE PATIENTS WITH ACUTE CORONARY SYNDROME, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-4, April‾2017