Volume : 6, Issue : 4, April - 2017

A STUDY OF "DEXMEDETOMIDINE FOR ATTENUATING STRESS RESPONSE AFTER LARYNGOSCOPE AND INTUBATION"

P S Shanmugam, Henin Mohan, Shakthi Vignesh

Abstract :

<p>&nbsp;<span style="font-size: 14pt; line-height: 115%; font-family: Calii, sans-serif;">Endotracheal intubation has become one of the frequently performed procedure in the practice of Anesthesia since the time of Introduction of Endotracheal Anesthesia in the last quarter of 19^th century.</span><span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:Calii;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">&nbsp; </span><span style="font-size: 14pt; line-height: 115%; font-family: Calii, sans-serif;">The process of Laryngoscopy &amp; Intubation are noxious stimuli &amp; therefore constitute period of extreme Haemodynamic stress and associated with intense sympathetic activity mediated by Hypertension &amp; Tachycardia¹.The increase in Pulse rate, Blood pressure are usually unpredictable, variable &amp; transistory.Pharmacological methods like use of &beta;-blockers, Vasodilator, Inhalation agents , Topical &amp; Intravenous Lidocaine, Narcotics, Calcium channel blockers has been tried. For attenuating the stress response,Dexmedetomidine is highly specific and selective &alpha;-2 adrenoreceptor agonist with &alpha;2:&alpha;1 binding selectivity ratio of 1620:1 compare to 220:1 for Clonidine^.Various studies have also found that Dexmedetomidine can decrease the Hemodynamic response to laryngoscopy and Intubation ^{3,4,5,6,7,8,9}.</span></p>