Volume : 6, Issue : 4, April - 2017

A STUDY TO ESTIMATE PREVALENCE OF OBSTRUCTIVE SLEEP APNOEA SYNDROME WITH MODIFIED BERLIN QUESTIONNAIRE: AN INDIAN SCENARIO

Rajendra Prasad, Ram Kishun Verma, Abhijeet Singh, Rajiv Garg, Sp Agarwal, Rc Ahuja

Abstract :

<p>&nbsp;</p> <h1 style="text-align:justify;line-height:200%"><span style="font-size:12.0pt;&#10;line-height:200%">Introduction:</span><span style="font-size:12.0pt;line-height:&#10;200%;font-weight:normal"> The burden of obstructive sleep apnoea syndrome (OSAS) is rapidly increasing in developing countries like India since the last decade.<o:p></o:p></span></h1> <h1 style="text-align:justify;line-height:200%"><span style="font-size:12.0pt;&#10;line-height:200%">Background</span><span style="font-size:12.0pt;line-height:&#10;200%;font-weight:normal">: To know the prevalence estimates for key symptoms and features that can indicate the presence of OSAS in Indian population.<o:p></o:p></span></h1> <p class="MsoBodyText3" style="margin-top:0in;line-height:200%"><b><span style="font-size:12.0pt;line-height:&#10;200%">Material and Methods: </span></b><span style="font-size:12.0pt;&#10;line-height:200%">A<b> </b>single centre cross-sectional study was conducted from August 2003 to July 2004 on consecutive apparently healthy attendants in age group of 25-64 years coming to outdoor of Department of Pulmonary Medicine, King George Medical University, Lucknow, India. We recorded data on a pre-designed proforma and took interview based on pre-tested Berlin Questionnaire (BQ) with some relevant modifications. Epworth sleepiness scale (ESS) score was also assessed for excessive daytime sleepiness (EDS). We also evaluated for some risk factors like smoking, alcoholism and use of sedative or tranquilizers.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:0in;text-align:justify;mso-pagination:&#10;none"><b><span style="font-size:12.0pt;&#10;line-height:200%">Results</span></b><span style="font-size:12.0pt;line-height:&#10;200%">: Out of 816 subjects approached, 702 (86%) were finally included in study (mean age 42.67 years; men n = 452 (64.4%), women n= 250 (35.6%). Out of these 3.7% (4.2% men, 2.8% women) were found to be at high risk for OSAS. Out of total studied population, 11.72% men and 14.8% women were obese (BMI </span><span style="font-size:12.0pt;line-height:200%;font-family:Symbol;mso-ascii-font-family:&#10;&quot;Times New Roman&quot;;mso-hansi-font-family:&quot;Times New Roman&quot;;mso-char-type:symbol;&#10;mso-symbol-font-family:Symbol">&sup3;</span><span style="font-size:12.0pt;line-height:200%"> 30 kg/m<sup>2</sup>) and 19.8% of obese population were at high risk for OSAS. Among high-risk patients for OSAS, 42.3% had hypertension. The mean ESS score was 5.17 </span><span style="font-size:12.0pt;line-height:200%;font-family:Symbol;mso-ascii-font-family:&#10;&quot;Times New Roman&quot;;mso-hansi-font-family:&quot;Times New Roman&quot;;mso-char-type:symbol;&#10;mso-symbol-font-family:Symbol">&plusmn;</span><span style="font-size:12.0pt;line-height:200%"> 2.58. Out of 702 subjects, 13 had clinically significant form of OSAS defined as snoring at least 3-4 times/week, EDS (ESS score </span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:Symbol;mso-ascii-font-family:&quot;Times New Roman&quot;;&#10;mso-hansi-font-family:&quot;Times New Roman&quot;;mso-char-type:symbol;mso-symbol-font-family:&#10;Symbol">&sup3;</span><span style="font-size:12.0pt;line-height:200%"> 11) and obesity (BMI </span><span style="font-size:12.0pt;line-height:200%;font-family:Symbol;mso-ascii-font-family:&#10;&quot;Times New Roman&quot;;mso-hansi-font-family:&quot;Times New Roman&quot;;mso-char-type:symbol;&#10;mso-symbol-font-family:Symbol">&sup3;</span><span style="font-size:12.0pt;line-height:200%"> 30 kg/m<sup>2</sup>), giving overall prevalence of OSAS at least 1.6% comprising 2.4% men and 0.8% women. <span style="letter-spacing:.3pt">Statistically significant risk-factors found for OSAS were </span>obesity, large neck size (</span><span style="font-size:12.0pt;line-height:200%;font-family:Symbol;mso-ascii-font-family:&#10;&quot;Times New Roman&quot;;mso-hansi-font-family:&quot;Times New Roman&quot;;mso-char-type:symbol;&#10;mso-symbol-font-family:Symbol">&sup3;</span><span style="font-size:12.0pt;line-height:200%">17 inch in male or </span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;Symbol;mso-ascii-font-family:&quot;Times New Roman&quot;;mso-hansi-font-family:&quot;Times New Roman&quot;;&#10;mso-char-type:symbol;mso-symbol-font-family:Symbol">&sup3;</span><span style="font-size:&#10;12.0pt;line-height:200%">15 inch in female), alcoholism and sedatives/ tranquilizers use. Male gender and smoking were associated with increased risk for OSAS but with no statistical significance.&nbsp; <o:p></o:p></span></p> <p><b><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:EN-US;&#10;mso-bidi-language:AR-SA">Conclusion</span></b><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:EN-US;&#10;mso-bidi-language:AR-SA">: OSAS is a common disease and there is high demand for its awareness, evaluation, diagnosis and management. Symptoms category 2 of BQ may be replaced with use of ESS score in developing countries like India</span></p>

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Rajendra Prasad, Ram Kishun Verma, Abhijeet Singh, Rajiv Garg, SP Agarwal, RC Ahuja, A STUDY TO ESTIMATE PREVALENCE OF OBSTRUCTIVE SLEEP APNOEA SYNDROME WITH MODIFIED BERLIN QUESTIONNAIRE: AN INDIAN SCENARIO, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-4, April‾2017


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