Volume : 6, Issue : 6, June - 2017
Comparative study between sublingual misoprostol and vaginal misoprostol for cervical priming prior to surgical termination of pregnancy in first trimester pregnancy.
Shashi Bala Singh, Arshi Perween
Abstract :
<p> <b style="text-align: justify;"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family: "Times New Roman",serif">Introduction: </span></b><span lang="EN-IN" style="text-align: justify; font-size: 14pt; line-height: 115%; font-family: "Times New Roman", serif;">Suction and evacuation had been standard method for surgical termination of first trimester pregnancy. Cervical priming before suction and evacuation is a critical step to reduce risk of cervical injury, uterine perforation, haemorrhage and incomplete evacuation associated with forceful mechanical dilatation. Misoprostol had been used as a cervical priming agent since long time either by oral, vaginal or sublingual route.</span></p> <p class="MsoNormal" style="text-align:justify"><b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family: "Times New Roman",serif">Aims and objectives:</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman",serif"> To compare the effectiveness, tolerability and acceptability of sublingual misoprostol compared to vaginal misoprostol as a cervical priming agent prior to first trimester vacuum aspiration.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify"><b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family: "Times New Roman",serif">Material and methods:</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman",serif"> In this randomised clinical study, a total of 100 women with the gestational age between 6 and 12 weeks were selected randomly and sequentially allocated into two groups of 50 each. Selected women were administered 400 μg of misoprostol 3 hours before suction and evacuation either by sublingual or vaginal route. The degree of cervical dilatation was the primary outcome to be observed and secondary outcomes being total duration of procedure , intra-operative blood loss and pain. The patient‘s tolerability was noted on the basis of side effects.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify"><b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family: "Times New Roman",serif">Results:</span></b><span lang="EN-IN" style="font-size: 14.0pt;line-height:115%;font-family:"Times New Roman",serif"> Demographically, both groups were similar. There was no significant difference in mean cervical dilatation (sublingual: 8.40 ± 1.17mm; vaginal: 8.03 ± 1.45mm), mean blood loss (sublingual: 43.36±6.28 ml; vaginal: 41.8 ± 6.43 ml) and duration for the procedure (sublingual: 8.31±2.83 minutes; vaginal: 7.95 ± 2.63 minutes). Pre-operative side effects were also similar.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify"><b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family: "Times New Roman",serif">Conclusion:</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman",serif"> Both sublingual and vaginal are effective route of misoprostol administration for cervical priming prior. Sublingual misoprostol has advantage of being more convenient to administer with high patient and staff acceptability.<o:p></o:p></span></p>
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Download PDF Journal DOI : 10.15373/2249555XCite This Article:
Shashi Bala Singh, Arshi Perween, Comparative study between sublingual misoprostol and vaginal misoprostol for cervical priming prior to surgical termination of pregnancy in first trimester pregnancy., GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-6 | ISSUE‾6 | JUNE-2017