Volume : 6, Issue : 6, June - 2017

The Liver in Sepsis in Early Childhood: An Autopsy Study.

Dr. Meenakshi Balasubramanian, Dr. Rawi Agrawal, Dr. Sushma Malik, Dr. Shilpa Lad

Abstract :

<p>&nbsp;<span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Sepsis, a leading cause of death in children between 1-4 years of age, occurs in response to infection. It commonly presents with hepatic dysfunction as seen clinically, biochemically and morphologically. </span><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">We aimed t</span><span lang="EN-IN" style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">o study the morphological changes in the liver in young children who died of sepsis. We also aimed to evaluate common presentations of sepsis during early childhood.</span><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"> The total number of autopsy cases in the 0-4 year&rsquo;s age group were 314, of which 185 cases were of sepsis (59%). Sinusoidal congestion was the most common microscopic feature, seen in 84.86% cases. Pneumonia was the most common primary focus for sepsis.</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:200%;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-bidi-font-family:Arial"><o:p></o:p></span></p>