Volume : 6, Issue : 6, June - 2017

A Comparative study of variations of Lipid Profile in different stages of Chronic Kidney Disease and Hemodialysis

Dr. Jayamohan Kokkat, Dr. Sandheep George Villoth, Dr. P S Prakash, Dr. Ivor Peter D Sa

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-family:&quot;Times New Roman&quot;,serif">Aim:</span></b><span style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif;"> Chronic kidney disease encompasses a spectrum of different patho-physiological processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate. The term chronic renal failure applies to the process of continuing significant irreversible reduction in number of nephrons. The National Kidney Foundation and the Dialysis Outcome Quality Initiative advisory board has approved the development of clinical practice guidelines to define CKD and to classify stages in the progression of kidney disease. Cardiovascular disease is a major cause of morbidity and mortality among patients with chronic renal failure. The aim of this study is to analyze the pattern of lipid profile variations in CKD patients in stages 3,4 and stage 5 on hemodialysis. <b>Design/Methods:</b>&nbsp; This is a cross sectional hospital based study and 100 subjects were categorized according to National Kidney Foundation and the Dialysis Outcome Quality Initiative guidelines on staging of CKD. <b>Results: </b>A rising trend of triglycerides and VLDL levels were observed as the stage of CKD progressed, which was statistically significant too. HDL cholesterol level were found to be lower in CKD patients as stages progressed. Total cholesterol, LDL and HDL levels decreased in hemodialysis population. <b>Conclusions:</b> We conclude that lipid abnormalities in CRF accelerates the progression of the renal failure and predisposes to atherosclerosis, hence it is worthwhile detecting and treating hyperlipidemia in CRF patients early on.</span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>