Volume : 6, Issue : 6, June - 2017

Recurrent Squamous Cell Carcinoma in a 12 year old boy with Xeroderma Pigmentosum

Dr. Udasimath. Shivakumarswamy, Dr. Vinay. K. N, Dr. Nagesha. K. R

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">Xeroderma pigmentosum (XP) is a rare autosomal-recessive disorder that appears in early childhood. Patients with XP are highly sensitive to ultraviolet radiation and are prone to develop multiple skin malignancies and can acquire Squamous cell carcinoma (SCC) at an early age.</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">SCC of the skin usually occurs in older patients and commonly develops from preexisting actinic keratosis. SCC is not uncommon in patients with xeroderma pigmentosum and mostly involves the face, head, neck, and scalp.</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%;&#10;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&quot;Times New Roman&quot;">Here, we present a case of recurrent squamous cell carcinoma of the face in a twelve-year-old boy with xeroderma pigmentosum. Child presented with complaints of maculopapular rashes with ulcerative lesions over the face since the age of nine years. Excisional biopsy of the ulcerative lesion, near nose, was diagnosed as squamous cell carcinoma. Past history also revealed that this lesion was a recurrent one and previously it was diagnosed as squamous cell carcinoma. The challenges of a child with XP who grows up in a sunny environment where the possibility of early onset of squamous cell carcinoma is extremely high in any suspected skin lesion is discussed here. <o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;&#10;text-align:justify;line-height:150%"><span style="font-size:12.0pt;line-height:&#10;150%;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&quot;Times New Roman&quot;">In sunny areas, proper education to the patient and their parents about ultra-violet light protection and early recognition of any suspicious lesion could be life-saving in XP patients.<o:p></o:p></span></p>