Volume : 6, Issue : 6, June - 2017

CAN IV FLUID THERAPY ALTER RENAL FUNCTION? PILOT STUDY ON COMPARISON OF BALANCED SALT SOLUTION, RINGER LACTATE AND NORMAL SALINE

Col Vikas Srivastava, Col Sanil Mohan

Abstract :

<p>&nbsp;<span style="font-family: Arial, sans-serif; font-size: 12pt; text-align: justify;">Objective. Kidney dysfunction in patients who had intestinal perforation and were exclusively on IV fluids were compared when different IV fluids were administered. Three IV fluids were compared 0.9% Normal Saline (NS), Ringer Lactate (RL) and Balanced Salt Solution (BSS).</span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Arial&quot;,sans-serif;&#10;mso-fareast-font-family:Arial">Material and Methods. Study was randomized double blind single centre. 50 patients were recruited in each of three limbs - NS, RL and BSS. Kidney parameters and serum electrolytes were monitored throughout the study period.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Arial&quot;,sans-serif;&#10;mso-fareast-font-family:Arial">Results. In NS limb, patients received a higher chloride load and consequently their serum chloride was higher than other two groups, which as statistically significant (NS=115, RL=103 &amp; BSS=100).&nbsp; <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">The incidence of stage 2 or 3 AKI as per KDIGO stage II or III was more in NS group 8 (16%) than in RL 4 (8%) and in BSS 3 (6%).<o:p></o:p></span></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span style="font-size: 12pt; line-height: 200%; font-family: Arial, sans-serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Conclusion. This study suggests that IV fluids with physiological levels of chloride maybe better than NS in preventing Renal Injury.<o:p></o:p></span></p>