Volume : 6, Issue : 6, June - 2017

Dediffrentiated Chondrosarcoma- A rare case report

Dr Ajay Kumar Shrivastava, Dr. Manoj Kumar Paswan, Dr Mohit Pradhan, Dr. Deepali Tirkey

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">Dedifferentiated </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">chondrosarcoma </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">was </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">first </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">proposed </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">in </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">1971 </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">by </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">Dahlin</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">and </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">Beabout</span><b style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">.^[1]</b><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;"> </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">It&nbsp; occurs &nbsp;in &nbsp;patients &nbsp;older &nbsp;than &nbsp;50 &nbsp;years &nbsp;and &nbsp;most &nbsp;commonly &nbsp;involves &nbsp;the &nbsp;femur, &nbsp;<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">pelvis&nbsp; and &nbsp;humerus.<b>^[2] &nbsp;</b>The &nbsp;male &nbsp;to &nbsp;female &nbsp;ratio &nbsp;is &nbsp;1.3:1. &nbsp;They &nbsp;account &nbsp;for &nbsp;10-15% &nbsp;of &nbsp;<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">all _&nbsp;chondrosarcomas &nbsp;and &nbsp;show &nbsp;an &nbsp;increased &nbsp;growth &nbsp;rate &nbsp;and &nbsp;rapid &nbsp;metastatic &nbsp;spread.<b>^[2]</b> &nbsp;_<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">Dedifferentiated &nbsp;chondrosarcoma &nbsp;refers &nbsp;to &nbsp;the &nbsp;presence &nbsp;of &nbsp;a &nbsp;poorly &nbsp;differentiated &nbsp;<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">sarcomatous &nbsp;component &nbsp;(osteosarcoma, &nbsp;fiosarcoma, &nbsp;rhabdomyosarcoma &nbsp;and &nbsp;<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">pleomorphic &nbsp;sarcoma &nbsp;with &nbsp;MFH &nbsp;like &nbsp;features) &nbsp;at &nbsp;the &nbsp;periphery &nbsp;of &nbsp;a &nbsp;typical &nbsp;low &nbsp;grade &nbsp;<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,serif">chondrosarcoma.&nbsp;<o:p></o:p></span></p>