Volume : 6, Issue : 6, June - 2017

BONE MARROW PROFILE IN OSTEOPOROSIS

Longjam Nilachandra Singh, Aten Jongkey, Longjam Darendrajit Singh, Shibu B, Tripti Swami, Kanti Rk, Akoijam Joy Singh

Abstract :

<p>&nbsp;Osteoporosis is a common metabolic bone disease character&shy;ized by decreases in bone mass and density. In the adult bone marrow, osteoblasts and adipocytes share a common precursor called mesenchymal stem cells. The plasticity between osteoblasts and adipocytes has important implications in the etiology of bone diseases such as osteoporosis. The pathological conditions linked to osteoporosis can change the bone marrow microenvironment and shift the mesenchymal stem cells fate to favor adipocytes over osteoblasts, and consequently decrease bone mass. A cross-sectional study was conducted in 150 patients (124 females &amp; 26 males) to assess the bone marrow profile in osteoporotic patients, who were diagnosed using Dual Energy X-ray Absorptiometry (DEXA). The study was conducted in the Department of Physical Medicine &amp; Rehabilitation, Regional Institute of Medical Sciences, Imphal, India from Feuary 2015 to March 2016. The study showed that the osteoporotic patients have hypocellular bone marrow.</p>