Volume : 6, Issue : 6, June - 2017

VARIATION OF SERUM UREA AND CREATININE LEVELS IN CKD PATIENTS IN EARLY MORNING AND AFTERNOON SAMPLES

Shah Sunil K. , Z. G. Badade, A. D. Deepak, Raj Santhini, Pandey Ashwani Kumar, Bhowad Shruti

Abstract :

<p>&nbsp;<b style="text-align: justify;"><i><span style="font-size: 14pt; font-family: &quot;Times New Roman&quot;, serif;">Aims &amp; Objectives</span></i></b><i style="text-align: justify;"><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">: The aim is to study variation of serum urea and creatinine levels in CKD patients in early morning and afternoon samples.</span></i></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;mso-line-height-alt:8.05pt;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;mso-line-height-alt:8.05pt;mso-layout-grid-align:&#10;none;text-autospace:none"><b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">Study Design</span></i></b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">: Observational &amp; prospective. <o:p></o:p></span></i></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;mso-line-height-alt:8.05pt;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">&nbsp;</span></p> <p class="MsoNoSpacing"><b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">Place and Duration of Study</span></i></b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">: The study was carried out in </span></i><span style="font-size:12.0pt;font-family:&#10;&quot;Times New Roman&quot;,serif">Department of Biochemistry and MGM Medical College and Hospital, Kamothe, Navi-Mumbai.&nbsp; <o:p></o:p></span></p> <p class="MsoNoSpacing"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;<o:p></o:p></span></p> <p class="MsoNoSpacing"><b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">Methodology</span></i></b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">: Total 80 subjects comprising of male and female aged between 30 to 60 years were recruited in the study after obtaining informed written consent. The serum levels of urea, &nbsp;and creatinine were estimated two times a day at morning 8am-9am and afternoon 2pm-4pm. The mean serum urea level and serum creatinine level at various durations was compared using one way ANOVA. <o:p></o:p></span></i></p> <p class="MsoNoSpacing"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:5.0pt;text-align:justify;text-justify:&#10;inter-ideograph;mso-line-height-alt:8.05pt;mso-layout-grid-align:none;&#10;text-autospace:none"><b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">Results</span></i></b><i><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">: In our study, we have not observed any significant variation in the case of serum urea and creatinine levels in morning and afternoon samples in CKD patients.&nbsp;<o:p></o:p></span></i></p>