Volume : 6, Issue : 6, June - 2017

VITAMIN D DEFICIENCY AND ITS ASSOCIATION WITH DEVELOPEMENT OF PREECLAMPSIA IN PRIMIGRAVIDA

Dr. T. G. Revathy, Dr. Vaseelabanu

Abstract :

<p>&nbsp;<b style="text-align: justify;"><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">AIM</span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; To study the association between Vitamin D deficiency and development of preeclampsia in primigravida and thereby natural and fetal outcome <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">SUBJECTS &amp; METHODS<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; This is a prospective randomised control study at govt Kasturba Gandhi Hospital, MMC.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Vitamin D2 level were taken from all selected patients between the gestational age 12 to 20 weeks.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Predictive range of Vitamin D2 level for development of preeclampsia was identified based on parameter like age, body mass index and gestational age. The statistical significance of their correlations was assessed using two sided p value. A p value of &lt;0.05 was considered statsically significant .<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">RESULT<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this study out of 200 patients 27 developed preeclampsia, 49&nbsp; developed gestational hypertension, 124 were normal. According to chi square test there is associations between development of Vitamin D levels and association of preeclampsia there is significant correlation with development of preeclampsia when Vitamin D levels lees than 12<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">CONCLUSION<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; This study shows there is significant association between Vitamin D deficiency and development of preeclampsia. Also Vitamin D supplementation in pregnancy will be a effective means of preventing preeclampsia.<o:p></o:p></span></p>