Volume : 6, Issue : 6, June - 2017

STUDY OF CRP, BMI AND LIPID PROFILE IN CORONARY ARTERY DISEASE

Sarika Kokane, Dr. Shrikant W. Masram, B B Murhar, M V Bimanpalli

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-size: 12pt; line-height: 200%; font-family: Georgia, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Background</span></b><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: Georgia, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">: Various studies have suggested the association between low grade chronic inflammation and Coronary Artery Disease (CAD). <b>Aim</b>: Present study was done to evaluate relationship between CRP, Body Mass Index (BMI), Lipid Profile&nbsp; in&nbsp; patients of CAD. In the present study BMI and serum levels of CRP, Lipid profile were compared between 100 cases of CAD and 100 age and gender matched controls. </span><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: Georgia, serif;">Unpaired t-test was performed to compare BMI, CRP and Lipid Profile between CAD case and control groups. Pearson correlation coefficient (r) was calculated to assess the correlation between BMI and CRP in CAD Case group, Lipid profile and CRP in CAD case group &amp; BMI and Lipid profile in CAD case group. Both the tests were two sided. The p value &lt;0.05 was considered as statistically significant. The</span><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: Georgia, serif;"> p value &lt; 0.001 was considered as highly significant </span><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: Georgia, serif;">and the p value &gt; 0.05 was taken as non-significant (NS). <b>Results</b>:<span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> </span>A highly significant increase in BMI, CRP, total cholesterol (TC), triglycerides (TG) and low density lipoprotein cholesterol (LDL-c) was found in the cases as compared to that in normal controls. Significantly higher CRP level in females as compared with males was found. A highly significant decrease in High density lipoprotein cholesterol (HDL-c) was found in the cases as compared to that in normal controls.<span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> The highly significant positive correlation is found between BMI and CRP in CAD patients. The relationship between CRP and Lipid Profile is found to be non-significant in CAD patients. The relationship between BMI and Lipid Profile is found to be non-significant in CAD patients. <b>Conclusion</b>: Chronic low grade inflammation and obesity is positively associated with CAD and the relationship is not independent of each other.&nbsp; Lipid profile is positively associated with CAD and the relationship between CAD and lipid profile is independent of CRP and BMI.</span></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Georgia&quot;,serif;mso-bidi-font-family:Arial"><span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><o:p></o:p></span></span></p>