Volume : 6, Issue : 7, July - 2017
EVALUATION OF ACTIVITY OF PLATELETS IN DIABETES MELLITUS - A KEY ROLE IN DIAGNOSIS
Dr. Manoharan A, Dr. Ravichandran. S, Prof. Dr. Pammy Sinha, Prof. Dr. Jayalakshmi. G
Abstract :
<p> <b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN">Introduction</span></b></p> <p class="MsoNormal" style="margin: 8.3pt 0in; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; font-family: "Times New Roman", serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Platelets </span><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; font-family: "Times New Roman", serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">or<span class="apple-converted-space"> </span>thrombocytes<span class="apple-converted-space"> </span> are small, disc shaped clear cell fragments which measure 2–3 µm in diameter,<span class="apple-converted-space"> </span>which are derived from its </span><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; font-family: "Times New Roman", serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">precursor <span class="apple-converted-space"> </span></span><span lang="EN-IN"><a href="http://en.wikipedia.org/wiki/Megakaryocyte" title="Megakaryocyte"><span style="font-size: 12pt; line-height: 150%; font-family: "Times New Roman", serif; color: windowtext; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; text-decoration: none;">megakaryocytes</span></a> by fragmention.</span><sup><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi"> </span></sup><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; font-family: "Times New Roman", serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> </span><span lang="EN-IN" style="font-size:12.0pt; line-height:150%;font-family:"Times New Roman",serif;mso-fareast-font-family: Calii;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi">They are anucleated cells which plays a vital role in hemostasis and thrombosis. Platelets normally circulate in the bloodstream in a quiescent state, but it gets activated following damage to the vessel wall, leading to rapid formation of a platelet aggregate or vascular plug and occlusion of the site of damage.</span><span class="emphi"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi"> </span></span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN">The morphological variations in assessing Mean Platelet Volume (MPV) have important implications for assessing the functional expressions of platelets. The activity of platelets can be very well observed in the mean platelet volume(MPV), which acts as</span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%; font-family:"Times New Roman",serif"> as a marker of platelet activity.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN"> </span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-IN">The MPV is affected by aging of platelets and varies according to the balance between production and destruction. Platelet count and MPV are strongly associated with prognosis in critically ill patients<span style="color:red">. Elevated MPV values are noted in </span></span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";color:red;mso-fareast-language:EN-IN">uncontrolled diabetes mellitus (DM).</span><span lang="EN-IN" style="font-size:12.0pt; line-height:150%;font-family:"Times New Roman",serif;mso-fareast-font-family: "Times New Roman";mso-fareast-language:EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin: 8.3pt 0in; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN">Objectives:</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin: 8.3pt 0in; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN">1.To compare the MPV values among diabetics along with healthy non-diabetic people.<o:p></o:p></span></p> <p class="MsoNormal" style="margin: 8.3pt 0in; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";mso-fareast-language:EN-IN">2. To determine the age and sex group among diabetic and non-diabetic patients.<o:p></o:p></span></p> <p class="MsoNormal" style="margin: 15.4pt 0in 7.7pt; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size:12.0pt;line-height: 150%;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman"; mso-fareast-language:EN-IN">Materials and Methods<o:p></o:p></span></b></p> <p class="p" style="margin: 8.3pt 0in; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN">The patients were classified as diabetic patients and non diabetic patients and mean platelet volume (MPV) were calculated. Totally 295 patients were taken for our study, out of which 180 were diabetic and 115 were non diabetic. Patient’s medical history was obtained. The parameters were analysed statistically.<o:p></o:p></span></p> <h3 style="margin: 15.4pt 0in 7.7pt; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%">Results<o:p></o:p></span></h3> <h3 style="margin: 15.4pt 0in 7.7pt; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; font-weight: normal;">Among diabetic patients, 120 patients were males and 60 patients were females and mean MPV was 11.0 fL. In 115 non-diabetic controls 82 patients were males and 33 patients were females and mean MPV was 9.5 fL. Among diabetics the mean age group was 55±5 and in non diabetics mean age group was 40±5. Among diabetic patients 30 patients(16.6%) showed clinical symptoms, in which they showed MPV higher than 11.5. <o:p></o:p></span></h3> <h3 style="margin: 15.4pt 0in 7.7pt; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Conclusion:<o:p></o:p></span></h3> <h3 style="margin: 15.4pt 0in 7.7pt; text-align: justify; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 150%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; font-weight: normal;">Mean platelet volume values are significantly elevated in uncontrolled diabetic patients when compared with non diabetic patients. And these patients with higher MPV will be more prone for complications. So, by assessing MPV values we can predict the diabetic patients whether they are prone to severity or not. MPV can be considered as a prognostic marker for disease progression for diabetes.<o:p></o:p></span></h3>
Keywords :
Cite This Article:
Dr.Manoharan A, Dr. Ravichandran.S, Prof.Dr.Pammy Sinha, Prof.Dr.Jayalakshmi.G, EVALUATION OF ACTIVITY OF PLATELETS IN DIABETES MELLITUS‾A KEY ROLE IN DIAGNOSIS, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-6 | ISSUE‾7 | JULY -2017