Volume : 6, Issue : 7, July - 2017

STUDY ON CORRELATION BETWEEN MATERNAL SERUM LDH LEVELS AND SEVERITY OF PRE-ECLAMPSIA MATERNAL AND PERINATAL OUT COME

Dr. T. G. Revathy, Dr. C. Dhivya

Abstract :

<p>&nbsp;<b style="text-align: justify;"><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">AIM:-</span></u></b></p> <p class="MsoListParagraphCxSpFirst" style="text-align:justify;text-indent:-.25in;&#10;line-height:150%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">1)<span style="font-variant-numeric: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: &quot;Times New Roman&quot;;">&nbsp;&nbsp;&nbsp; </span></span><!--[endif]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">To Compare Serum LDH Levels in normal pregnant women and in women with pre-eclampsia.<o:p></o:p></span></p> <p class="MsoListParagraphCxSpMiddle" style="text-align:justify;text-indent:-.25in;&#10;line-height:150%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">2)<span style="font-variant-numeric: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: &quot;Times New Roman&quot;;">&nbsp;&nbsp;&nbsp; </span></span><!--[endif]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">To find the relationship between severe LDH levels and of pre eclampsia maternal and perinatal outcome.<o:p></o:p></span></p> <p class="MsoListParagraphCxSpMiddle" style="text-align:justify;text-indent:-.25in;&#10;line-height:150%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">3)<span style="font-variant-numeric: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: &quot;Times New Roman&quot;;">&nbsp;&nbsp;&nbsp; </span></span><!--[endif]--><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">To find prognostic value of LDH in maternal morbidity in pre eclampsia.<o:p></o:p></span></p> <p class="MsoListParagraphCxSpLast" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">MATERIALS &amp; METHODS:<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Study design&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Prospective Comparative Study&nbsp;&nbsp;&nbsp; <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Study Period&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; August 2015 to August 2016<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Place of study&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Department of obstetrics and gynaecology <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Government Kasturba Gandhi Hospital <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Triplicane Chennai.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Sample Size&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 200<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Estimation of Maternal serum LDH <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">Results: <o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this Study There was no statistical significance with respect to age, BMI, Socio economic status.,LDH levels were found higher among <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">pre eclampsia group compared to healthy normal pregnant women. Among the pre eclampsia group highlevel of LDH were seen in severe pre eclampsia when compared to mild pre eclampsia.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b><u><span lang="EN-IN" style="font-size:16.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">Conclusion:<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Elevated levels of maternal serum Lactate dehydrogenase (LDH) is indicative of cellular damage and dysfunction can be used as biochemical marker because it reflects the severity of disease, because of complications and perinatal outcome. Increased LDH methods close monitoring and management to decrease both maternal and fetal morbidity and mortality.<o:p></o:p></span></p>

Keywords :


Cite This Article:

DR. T.G. REVATHY, DR. C. DHIVYA, STUDY ON CORRELATION BETWEEN MATERNAL SERUM LDH LEVELS AND SEVERITY OF PRE-ECLAMPSIA – MATERNAL AND PERINATAL OUT COME, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-6 | ISSUE‾7 | JULY -2017


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