Volume : 2, Issue : 4, April - 2013

Beneficial Action of Indigofera Tinctoria (LINN.) on Hepatorenal of Glycogen and Protein Levels Against Paracetamol Induced Hepatotoxicity in Rats

F. Annie Felicia, M. Muthulingam

Abstract :

The therapeutic potential of Indigofera tinctoria was evaluated by paracetamol induced hepatotoxicity in rats. Male albino wistar rats were orally treated with Indigofera tinctoria (75, 150 and 300 mg/kg body weight) or silymarin (25 mg/kg) daily with administration of paracetamol (3 gm/kg body weight– p o) only one day. Paracetamol induced hepatotoxicity and significantly decreased the levels of protein and glycogen in liver and kidney as compared with control group. Treatment with Indigofera tinctoria or silymarin consecutively for twenty eight days could significantly increase the levels of protein and glycogen in liver and kidney when compared with paracetamol alone treated rats.