Volume : 5, Issue : 5, May - 2016

Stress as antibiotic resistance determinant in bacteria: A Homology Model Perspective

Alok Jha

Abstract :

<p>&nbsp;The hypothesis that bacteria would likely attain resistance to any antibiotic treatment given the right circumstance. Moreover, since antimicrobials are growth inhibiting stressors that often elicit protective responses in bacteria, these agents can provoke their own resistance promoting responses. The universal stress proteins have functional roles in adhesion, motility and oxidative stress resistance. However, some forms are not directly involved in stress resistance but are essential. Here, structural features of universal stress proteins from E.coli and Corynebacteriales bacterium complexed with dioxygen and lactum ring antibiotic Penicillin have been presented through docking and homology modeling approach. The study underlines the effect of oxygen and lactum antibiotic Penicillin on the stress protein derived from both gram + and &ndash; bacteria through identified amino acid residues and substrate interactions. The structure models can provide clues to structurally understand the importance of stress responses as resistance determinants and appreciate their value as therapeutic targets.</p>