Volume : 8, Issue : 7, July - 2019

Effect of Salicylate on Albino Rats by Study of Serum Globulin pattern

Anjali Bhargava, Deepika Bhargava

Abstract :

Salicylate is widely used as an analgesic in medicine. It has been observed that many of the deadly effigies of salicylate have resulted in the human body. Therefore, the persentant study was designed to evaluate if there is any change in albumin protein in serum after liver damage due to salicylate treatment, if there is a compensatory binding reaction and the other in serum for salicylate treatment model. The young albino rats of Vistar Strain, weighing between 180 and 200 grams were selected for experimental work, were taken and fed a standard diet for two weeks. After this, they were divided into 3 groups and treated with sodium salicylate for three weeks and six weeks, respectively. After treatment with salicylate for three weeks and six weeks, the body weight of the rats had decreased; after treatment with sodium salicylate, the reason for the reduction in body weight could be the reason. Albumin was slightly reduced, because after 3 weeks of salicylate treatment, beta-globulin had slightly increased. Albumin was significantly reduced and after 6 weeks of salicylic treatment, alpha-1 and beta-1 globulin significantly increased. There is no significant change in the other globulin fraction after 6 weeks of salicylate treatment. There is a significant gradual reduction in the transferrin globulin in rats treated with salicylate, as compared to that which inhibits the ion transport mechanism of ions from Fe ions