Volume : 5, Issue : 11, November - 2016

Impact of Glutathione on Male Fertility

Dr. Alpana Tyagi, Dr. Hyacinth Highland, Dr. Rajula T

Abstract :

<p>&nbsp;The equiliium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. Growing evidence indicates that oxidative stress can be a primary cause of male infertility. Non-enzymatic antioxidants play an important protective role against oxidative damages and lipid peroxidation. Glutathione has a central role in the defense against oxidative damage; however, the data on glutathione concentrations in the semen of infertile men are limited. To expand this knowledge the concentrations of total glutathione were assessed in spermatozoa and seminal plasma of patients of unexplained infertility. This study demonstrated that intracellular glutathione levels of spermatozoa are decreased in unexplained infertile cases.</p>