Volume : 8, Issue : 4, April - 2019

Hepatoprotective effect of Asparagus racemosus aqueous extract on paracetamol induced stress in the fish Anabas testudineus

Renuka M. R.

Abstract :

Present study clearly demonstrates the ameliorating effects of Asparagus racemosus extract on hepatic injury caused by repeated paracetamol dosing in fishes. Histopathological observations and quantitative estimation of serum alkaline phosphatase activity were used as indices for studying the damage caused by paracetamol and the ameliorative effect of Asparagus racemosus. Repeated administration of paracetamol caused a sharp increase in the serum alkaline phosphatise activity as indicated by the high values in treated group of fishes in comparison with control group. Histopathological study also revealed altered liver architecture as evidence by swollen aopptotic hepatocytes with coarse granular cytoplasm and compressed sinusoids. Severe lymphocytic infiltration was also noticed. In Asparagus treated group liver architecture and alkaline phosphatise activity were normal. When the paracetamol injected group was treated with Asparagus extract there was a significant decline in elevated ALP level. The hepatic tissue architecture also showed signs of cure as treated with Asparagus. When fishes pre treated with Asparagus was later treated with paracetamol there was lesser degree of damage to liver tissue and only slight variation in alkaline phosphatise activity was recorded. All these result clearly indicates that the plant Asparagus has promising ability to cure hepatic damage.