Volume : 6, Issue : 3, March - 2017

EFFECT OF SIX WEEKS CONDITIONING PROGRAMME ON PHYSICAL FITNESS STATUS OF PROFESIONAL PHYSICAL EDUCATION STUDENTS

Atanu Kumar Nanda

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">Computational approaches have attracted tremendous attention for the prediction of protein-protein interaction networks and also because of the ability of such methods to validate the results. In this study, we report protein-protein interaction (PPI) interfaces of bacterial universal stress protein, UspC and chromosome partitioning protein, mukB by using </span><i style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">in silico</i><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;"> methods. Universal stress protein, UspC has a functional role in providing resistance to DNA damaging agents and the predicted partner chromosome partitioning protein, mukB is involved in chromosome segregation and condensation and associated signal transduction. The study reveals the hot spot residues in the protein-protein interaction interface and also the solvation free energy gain upon formation of the assembly that indicates the areas to be targeted with small molecules. The geometry of PPI interfaces also indicates the possibility of finding new therapeutic interventions.</span></p> <p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>