Volume : 8, Issue : 3, March - 2019

A STUDY OF COAGULATION PROFILE IN DENGUE FEVER IN TERTIARY CARE HOSPITAL

Dr. Prakruthi J, Dr. Mohammed Rifaz, Dr. Musthyala Manoj

Abstract :

Background: In Dengue fever deaths are due to hemorrhagic complications. Hemorrhage in DF is due to thrombocytopenia or clotting factors abnormalities.There is limited literature on coagulation abnormalities, fiin degradation products and D-dimer.thus it makes very important Methods: The study was done in Yenepoya medical college hospital -A tertiary care hospital. Total of 60 patients were taken out of which 30 were cases and 30 were healthy controls. Detailed history, general, physical and systemic examination was done. Laboratory parameters for tests Dengue NS1, IgM and IgG, CBC, PT/INR, APTT, FDP, D-dimer, were done. Results: The results of our study show that coagulation profile is impaired in Dengue Fever cases with FDP and D-dimer being positive and APTT being higher than that of controls. However impairment of APTT was clinically not significant. Also cases with DHF – were significantly associated with elevated D-dimer and FDP when compared with Dengue Fever cases. Conclusion: In conclusion, coagulopathy in Dengue Fever with Thrombocytopenia may indicate secondary Dengue infection and may predict Dengue hemorrhagic fever and its complications. FDP or D-dimer could be a useful tool to predict which patient needs monitoring for bleeding. Since D-dimer is expensive, and not all set ups will have facilities to estimate the same, we strongly recommend that FDP can be a part of Dengue hemorrhagic fever work up.