Volume : 8, Issue : 3, March - 2019

STUDY OF CHANGES IN LEVELS OF LDH AND GGT IN PREECLAMPSIA PATIENTS

Dr. Utsav Parmar, Dr. Asha Khubchandani, Dr. Pragna Sharma

Abstract :

Background- Preeclampsia is classified under hypertensive disorders of pregnancy (HDP). There is widespread endothelial dysfunction leading to hypertension and damage to vital organs such as liver, kidney, ain etc. Damage to such organs may lead to elevation in serum levels of specific enzymes and metabolites which can be used for predicting severity of the disease. Objectives- This study was done to compare serum levels of lactate dehydrogenase(LDH) and gamma glutamyl transferase(GGT) among women with preeclampsia and normal pregnancy. Materials and methods- Case control study was done taking 50 women with preeclampsia (cases) and 50 normotensive pregnant women (controls). Serum levels of LDH and GGT were measured using commercially available kits. Statistical analysis was done. Results- Serum levels of LDH and GGT were significantly increased in women with preeclampsia compared with controls. Conclusion- High levels of GGT and LDH may be useful for the monitoring and correct management of preeclampsia to decrease maternal and fetal morbidity and mortality.