Volume : 8, Issue : 3, March - 2019

Study on Utility of Ki-67 as a proliferation marker in thyroid lesions

Dr. Sivaelangovan. R, Dr. Veni. A

Abstract :

Objectives:This study was conducted to assess the utility of Ki-67 as a proliferation marker in nonneoplastic and neoplastic lesions of thyroid. To study the role of Immunohistochemical proliferative marker Ki 67 in thyroid lesions. Summary: The thyroid gland is unique among endocrine glands. It is the first endocrine gland to appear in the foetus. The thyroid gland is affected by a variety of pathological lesions that are manifested by various morphologies including developmental, inflammatory, hyperplastic and neoplastic pathology which are quiet common in the clinical practice. In the two and half year study period 1123 specimens were from various sites in head and neck region such as Scalp, periorbital region, ear, nose, cheek , lip, tonsil , tongue, thyroid, salivary glands and lymph nodes. Out of these 117 specimens were from thyroid and these cases were taken for this study. Ki-67 is an IgG1 type murine monoclonal antibody raised against a crude nuclear fraction of Hodgkin‘s disease-derived cell line L-428. Ki- 67 marker study may be helpful in distinguish undifferentiated areas from differentiated areas in a mixed type of thyroid cancer. Ki-67 labeling index (LI) show progressive increase from multinodular goiter to to malignant neoplastic lesions.